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KMID : 0882420060710010058
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Korean Journal of Medicine
2006 Volume.71 No. 1 p.58 ~ p.66
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Factors affecting serum levels of adipokines in Korean male patients with nonalcoholic fatty liver disease
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Oh Se-Yong
Cho Yong-Kyun
Yoo Tae Woo
Park Jung-Ho
Kim Hong-Joo
Park Dong-Il
Sohn Chong-Il
Jeon Woo-Kyu
Kim Byung Ik
Jung Chan-Hee
Rhee Eun-Jung
Lee Won-Young
Kim Sun-Woo
Oh Ki-Won
Yoon Eun-Joo
Oh Eun-Sook
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Abstract
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Background : Adipokines are associated with various metabolic disorders including insulin resistance, obesity and dyslipidemia. Metabolic disorders have also been reported to be associated with nonalcoholic fatty liver disease (NAFLD). We aimed to estimate changes in serum adipokines levels according to the degrees of steatosis and to determine independent factors influencing serum adipokines levels in Korean male patients with NAFLD.
Methods : 65 Korean male patients were subjected. The degrees of steatosis were stratified into the three groups, Group I: normal liver (27 subjects), Group II: mild fatty liver (24 subjects) and Group III: moderate to severe fatty liver (14 subjects), according to ultrasonographic liver findings. The anthropometric parameters, fasting serum adipokine levels including leptin, adiponectin and resistin were measured in all subjects. The level of insulin resistance was estimated using the HOMA-IR.
Results : Serum leptin levels were significantly different among the three groups (mean±SD: Group I (2.052±1.071), Group II (2.879±1.016), Group III (4.457±1.965 ng/mL), p<0.001). Serum adiponectin and resistin levels were not significantly different among the three groups (p=0.184, p=0.649, respectively). BMI and HOMA-IR were independent factors of changes in serum leptin levels(p=0.026, p=0.001, respectively), but independent factors of changes in serum adiponectin and resistin
levels were not observed.
Conclusion : Our study support a indirect role to induce metabolic disorder for leptin in the pathogenesis of NAFLD, but do not support roles for adiponectin and resistin in the pathogenesis of NAFLD. BMI and HOMA-IR were only independent factors of changes in serum leptin levels.
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KEYWORD
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Fatty liver, Leptin, Adiponectin, Resistin
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